The rapidly evolving COVID-19 pandemic is causing unprecedented levels of suffering globally and Africa remains severely threatened. The global progression of the disease and the associated mortality to date is a major cause of concern. The African Union’s priority in the face of this pandemic is the safety and health of all workers and the public. It is against this background that these guidelines were developed by the AUC-Department of Social Affairs, Africa-CDC, AUDA-NEPAD and ILO, in consultation with Business Africa, OATUU and ITUC – Africa. The guidelines aim to provide broad principles of infection prevention and control of COVID-19 for workers, employers and policymakers. These guidelines are not meant to replace existing government response procedures and occupational health and safety measures but rather, to complement them. These guidelines are in line with occupational safety and health management systems as espoused by the International Labour Organization and they also take into consideration measures set in the COVID-19 guidelines adopted by several member states.